Metabolomics

The research field of metabolomics deals with the analysis of the entire set of metabolites in a cell or organism of interest, meaning the small-molecule analytes with a molecular mass of below 1500 Da by common definitions. Metabolomics workflows involve targeted quantification and/or non-targeted identification strategies aiming at high metabolite coverage. Both targeted and non targeted analysis demand efficient metabolite extractions as well as selective and sensitive analytical tools. In the Koellensperger group, we develop optimized sample preparation protocols and novel multidimensional measurement platforms based on liquid chromatography and mass spectrometry.

Key projects:

› Separation techniques ‹

› Non-targeted data processing ‹

› Tumor models ‹

› Single cell metabolomics ‹

› Standardization ‹

› ISOtopic solutions ‹

Cooperation partners Metabolomics:

Department of Biotechnology, Department of Chemistry, University of Natural Resources and Life Sciences, Austrian Centre of Industrial Biotechnology (ACIB, http://www.acib.at), project cellular analysis within EQ-VIBT (http://eq-vibt.boku.ac.at/)
Walter Berger, Petra Heffeter, Institute for Cancer Research, Medical University of Vienna
Lukas Kenner, Department of Pathology, Medical University of Vienna
Michael A. Jakupec, Christian Kowol, Bernard Keppler, Institute of Inorganic Chemistry, University of Vienna
Thomas Stimpfl, Birgit Reiter, Department of Laboratory Medicine, MedUni Wien
Gerrit Hermann, ISOtopic solutions, Vienna
Giorgia Del Favero, Benedikt Warth, Doris Marko, Department of Food Chemistry and Toxicology, University of Vienna
Christopher Gerner, Institute of Analytical Chemistry, University of Vienna
Wolfram Weckwerth, Molecular Systems Biology, University of Vienna

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